Sensing of tryptophan by a non-toxic cobalt( ii ) complex

A non-toxic, hemocompatible, fluorescent probe as cobalt( ii ) based complex [Co(PS) 4 ](ClO 4 ) 2 ( 1 ) (PS: N -pyridylsalicylaldimine) was successfully synthesized and characterised by single crystal X-ray diffraction studies. The structural analysis revealed that 1 exhibits intramolecular π–π int...

Full description

Saved in:
Bibliographic Details
Published inRSC advances Vol. 6; no. 98; pp. 95888 - 95896
Main Authors Jana, Swapan Kumar, Mandal, Amit Kumar, Kumar, Anoop, Puschmann, Horst, Hossain, Maidul, Dalai, Sudipta
Format Journal Article
LanguageEnglish
Published 01.01.2016
Subjects
Amino acids
Binding
Constants
Diffraction
Fluorescence
Mathematical analysis
Quenching
X-rays
Online AccessGet full text

Cover

More Information
Summary:A non-toxic, hemocompatible, fluorescent probe as cobalt( ii ) based complex [Co(PS) 4 ](ClO 4 ) 2 ( 1 ) (PS: N -pyridylsalicylaldimine) was successfully synthesized and characterised by single crystal X-ray diffraction studies. The structural analysis revealed that 1 exhibits intramolecular π–π interaction. The recognition ability of 1 towards various amino acids and proteins were studied by UV-vis and fluorescence spectroscopy. The titled complex selectively sense the Trp by reducing its internal fluorescence quenching. It also sense BSA with a detection limit of 56 nM. The binding constant of 1 was analysed by Hill's equation and it was found that it binds to Trp and BSA in the order of 10 3 and 10 4 respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2046-2069
2046-2069
DOI:10.1039/C6RA16086G