Effect of immunotherapy on the kinetics of proliferation of a transplanted rat rhabdomyosarcoma

Our experiment confirms the effect of BCG and of neuraminidase (VCN) associated with mitomycine C (MitoC) treated tumoral cells on a rhabdomyosarcoma serially transplanted in a rat, which have been shown to prevent or to delay the growth of many experimental tumors and also prolonged the survival ti...

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Bibliographic Details
Published inEuropean journal of cancer Vol. 14; no. 10; pp. 1077,1087 - 1085,1088
Main Authors Gia, Do The, Loisillier, F.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1978
Subjects
Animals
Antigens, Neoplasm
BCG Vaccine - therapeutic use
Cell Division
Immunotherapy
Kinetics
Liver - pathology
Lymph Nodes - pathology
Mitomycins - pharmacology
Necrosis
Neuraminidase - therapeutic use
Rats
Rhabdomyosarcoma - immunology
Rhabdomyosarcoma - pathology
Rhabdomyosarcoma - therapy
Sarcoma, Experimental - immunology
Sarcoma, Experimental - pathology
Sarcoma, Experimental - therapy
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Summary:Our experiment confirms the effect of BCG and of neuraminidase (VCN) associated with mitomycine C (MitoC) treated tumoral cells on a rhabdomyosarcoma serially transplanted in a rat, which have been shown to prevent or to delay the growth of many experimental tumors and also prolonged the survival time of the animals. We have determined the effect of active immunotherapy on some kinetic parameters on the tumor growth. The NS 104 tumor may provide a tool to determine, whether this action of immunotherapy on resting cells is also true for other types of tumors.
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ISSN:0014-2964
DOI:10.1016/0014-2964(78)90063-4