Reactions of 3-amino-1,2,4-triazine with coupling reagents and electrophiles

Analogs of a new heterocyclic system were obtained from the reactions of 3-amino-1,2,4-triazine with coupling reagents such as boronic acids, and terminal alkynes in the presence of a palladium catalyst. Other reactions such as amination of the triazine at position 5, followed by electrophilic react...

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Bibliographic Details
Published inHeterocyclic Communications Vol. 28; no. 1; pp. 157 - 163
Main Authors Bvumbi Mpelegeng Victoria, Nemudzivhadi Anza Imanuel, Sengane Musiiwa Victoria, Moleele Simon Mnyakeni
Format Journal Article
LanguageEnglish
Published Berlin Walter de Gruyter GmbH 16.11.2022
De Gruyter
Subjects
3-amino-1,2,4-triazine
Alkynes
benzoylated
Coupling
electrophilic
heterocyclic
Isocyanates
monoureido
Palladium
Reagents
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Summary:Analogs of a new heterocyclic system were obtained from the reactions of 3-amino-1,2,4-triazine with coupling reagents such as boronic acids, and terminal alkynes in the presence of a palladium catalyst. Other reactions such as amination of the triazine at position 5, followed by electrophilic reactions with phenyl isocyanates and benzoyl chlorides, were performed to form new monoureido and benzoylated compounds.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2022-0149