The effect of operative duration on the outcome of colon cancer procedures

• Published in: Surgical endoscopy Vol. 36; no. 7; pp. 5076 - 5083
• Main Authors: Guidolin, Keegan, Spence, Richard T., Azin, Arash, Hirpara, Dhruvin H., Lam-Tin-Cheung, Kimberley, Quereshy, Fayez, Chadi, Sami
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2022; Springer Nature B.V
• Subjects: Abdominal Surgery; Colectomy - adverse effects; Colectomy - methods; Colonic Neoplasms - complications; Colonic Neoplasms - surgery; Colorectal cancer; Datasets; Endoscopy; Gastroenterology; Gynecology; Hepatology; Humans; Infections; Laparoscopy; Laparoscopy - adverse effects; Laparoscopy - methods; Length of Stay; Medicine; Medicine & Public Health; Morbidity; Mortality; Operative Time; Patients; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Postoperative Complications - surgery; Proctology; Quality improvement; Retrospective Studies; Surgery; Surgical anastomosis; Treatment Outcome; Colectomy; Operative time; Colon cancer; Complications; Operative duration; Colorectal cancer
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-021-08871-7

Background Prolonged operative duration has been associated with increased post-operative morbidity in numerous surgical subspecialties; however, data are limited in operations for colon cancer specifically and existing literature makes unwarranted methodological assumptions of linearity. We sought to assess the effects of extended operative duration on perioperative outcomes in those undergoing segmental colectomy for cancer using a methodologically sound approach. Methods We conducted a retrospective cohort study of patients undergoing segmental colectomy for cancer between 2014 and 2018, logged in the National Surgical Quality Improvement Program datasets. Our primary outcome was a composite of any complication within 30 days; secondary outcomes included length of stay and discharge disposition. Our main factor of interest was operative duration. Results We analyzed 26,380 segmental colectomy cases, the majority of which were approached laparoscopically (64.95%) and were right sided (62.93%). Median operative duration was 152 (95% CI 112–206) minutes. On multivariable regression, increased operative duration was linearly associated with any complication (OR = 1.003, 95% CI 1.003–1.003, p  < 0.0001) in the overall cohort, as was length of stay ( p  < 0.0001). All subgroups except for the laparoscopic left colectomy group were linearly associated with operative duration. In the laparoscopic left colectomy group, an inflection point in the odds of any complication was found at 176 min (OR = 1.39, 95% CI 1.20–1.61, p  < 0.0001). Conclusions This study suggests that the risk of perioperative complications increases linearly with increasing operative duration, where each additional 30 min increases the odds of complication by 10%. In those undergoing laparoscopic left colectomy, the risk of complications sharply increases after ~ 3 h, suggesting that surgeons should aim to complete these procedures within 3 h where possible.