Monitoring of hemodynamic change in patients with carotid artery stenosis during the tilt test using wearable near-infrared spectroscopy

• Published in: Advances in experimental medicine and biology Vol. 789; p. 463
• Main Authors: Igarashi, Takahiro, Sakatani, Kaoru, Fujiwara, Norio, Murata, Yoshihiro, Suma, Takeshi, Shibuya, Tadashi, Hirayama, Teruyasu, Katayama, Yoichi
• Format: Journal Article
• Language: English
• Published: United States 2013
• Subjects: Adult; Aged; Blood Pressure - physiology; Carotid Stenosis - metabolism; Carotid Stenosis - physiopathology; Cerebrovascular Circulation; Female; Hemodynamics; Hemoglobins - metabolism; Homeostasis - physiology; Humans; Ischemic Attack, Transient - metabolism; Ischemic Attack, Transient - physiopathology; Male; Monitoring, Physiologic - methods; Oxyhemoglobins - metabolism; Spectroscopy, Near-Infrared - methods; Tilt-Table Test - methods
• ISSN: 0065-2598
• DOI: 10.1007/978-1-4614-7411-1_62

Transient ischemic attack (TIA) is a major complication in patients with carotid artery stenosis. Patients with severe stenosis sometimes complain of orthostatic dizziness, such as syncope. The purpose of this study was to examine the usefulness of near-infrared spectroscopy (NIRS) for evaluating cerebral circulation in patients with carotid artery stenosis during head-up tilt test (HUTT). Fourteen patients with carotid artery stenosis and nine normal control subjects participated. In addition to blood pressure monitoring, hemoglobin (Hb) values (oxy-Hb, deoxy-Hb, and total Hb) were recorded by a wearable NIRS instrument with a high time resolution during HUTT. Oxy-Hb, which decreased initially when the test table was elevated, subsequently increased in normal volunteers and patients with carotid artery stenosis and did not differ significantly between the two groups. However, the oxy-Hb reduction in the carotid artery stenosis group (-0.02 ± 0.03 a.u.) at 30 s after elevation of the table was significantly larger than in the normal group (0.02 ± 0.02 a.u., P < 0.01). Our results indicate that oxy-Hb reduction in patients with carotid artery stenosis may be related to orthostatic dizziness. We concluded that NIRS monitoring is useful for evaluating cerebral autoregulation in patients with severe carotid artery stenosis.