Denticulatains A and B: unique stilbene–diterpene heterodimers from Macaranga denticulata

Two novel heterodimers, denticulatains A ( 1 ) and B ( 2 ), were isolated from the fronds of Macaranga denticulata . They possess an unprecedented stilbene–diterpene-type skeleton, which represents a unique class of prenylated stilbene. Their structures were elucidated by comprehensive analyses of e...

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Published inRSC advances Vol. 5; no. 18; pp. 13886 - 13890
Main Authors Yang, Da-Song, Li, Zi-Lei, Wang, Xue, Yan, Hui, Yang, Yong-Ping, Luo, Huai-Rong, Liu, Ke-Chun, Xiao, Wei-Lie, Li, Xiao-Li
Format Journal Article
LanguageEnglish
Published 2015
Subjects
Inhibition
Nuclear magnetic resonance
Spectroscopic analysis
Stilbene
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Summary:Two novel heterodimers, denticulatains A ( 1 ) and B ( 2 ), were isolated from the fronds of Macaranga denticulata . They possess an unprecedented stilbene–diterpene-type skeleton, which represents a unique class of prenylated stilbene. Their structures were elucidated by comprehensive analyses of extensive NMR and MS spectroscopic data. Compounds 1 and 2 exhibited inhibitory activity against acetylcholinesterase with the inhibition ratios of 22.1% and 27.5%, respectively, at a concentration of 50 μM.
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ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA14805C