Heart failure and atrial fibrillation: new concepts in pathophysiology, management, and future directions

A bidirectional pathophysiological link connects heart failure and atrial fibrillation, creating a frequent and challenging comorbidity, which includes neurohormonal hyperactivation, fibrosis development, and electrophysiologic remodeling, while they share mutual risk factors. Management for these d...

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Published inHeart failure reviews Vol. 27; no. 4; pp. 1201 - 1210
Main Authors Tsigkas, Grigorios, Apostolos, Anastasios, Despotopoulos, Stefanos, Vasilagkos, Georgios, Kallergis, Eleftherios, Leventopoulos, Georgios, Mplani, Virginia, Davlouros, Periklis
Format Journal Article
LanguageEnglish
Published New York Springer US 01.07.2022
Springer Nature B.V
Subjects
Beta blockers
Cardiac arrhythmia
Cardiology
Cardiovascular disease
Congestive heart failure
Diabetes
Drug therapy
Ejection fraction
Fibrillation
Fibrosis
Heart failure
Medical prognosis
Medicine
Medicine & Public Health
Mortality
Pacemakers
Pathophysiology
Pharmaceuticals
Quality of life
Risk factors
Weight control
Heart failure
Rhythm control
Anticoagulation
Treatment
Atrial fibrillation
Rate control
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Summary:A bidirectional pathophysiological link connects heart failure and atrial fibrillation, creating a frequent and challenging comorbidity, which includes neurohormonal hyperactivation, fibrosis development, and electrophysiologic remodeling, while they share mutual risk factors. Management for these devastating comorbidities includes most of the established treatment measures for heart failure as well as rhythm or rate control and anticoagulation mostly for atrial fibrillation, which can be achieved with either pharmaceutical or non-pharmaceutical approaches. The current manuscript aims to review the existing literature regarding the underlying pathophysiology, to present the novel trends of treatment, and to predict the future perspective of these two linked diseases with the numerous unanswered questions.
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ISSN:1382-4147
1573-7322
DOI:10.1007/s10741-021-10133-6