Protective effects of fowl-origin cadmium-tolerant lactobacillus against sub-chronic cadmium-induced toxicity in chickens

• Published in: Environmental science and pollution research international Vol. 29; no. 50; pp. 76036 - 76049
• Main Authors: Chen, Da-Wei, Li, Hui-Jia, Liu, YinYin, Ma, Li-Na, Pu, Jun-Hua, Lu, JunXian, Tang, Xiu-Jun, Gao, Yu-shi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2022; Springer Nature B.V
• Subjects: Adsorption; Antibacterial activity; Antiinfectives and antibacterials; Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Bacteria; Biocompatibility; Cadmium; Chickens; Drug resistance; Duodenum; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; Environmental science; Farms; Food chains; In vivo methods and tests; Kidneys; Lactic acid; Lactic acid bacteria; Liver; Livestock; Poultry; Poultry farming; Probiotics; Public health; Research Article; Salinity tolerance; Salt tolerance; Strains (organisms); Toxicity; Waste Water Technology; Water Management; Water Pollution Control; Cadmium; Lactic acid bacteria; Chicken; Biosorption; Toxicity
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-022-19113-1

Cadmium (Cd) directly endangers poultry health and indirectly causes harm to human health by food chain. Numerous studies have focused on removing Cd using lactic acid bacteria (LAB). However, there is still a lack of in vivo studies to validate whether Cd can be absorbed successfully by LAB to alleviate Cd toxicity. Here, we aimed to isolated and screened poultry-derived Cd-tolerant LAB with the strongest adsorption capacity in vitro and investigate the protective effect of which on sub-chronic Cd toxicity in chickens. First, nine Cd-tolerant LAB strains were selected preliminarily by isolating, screening, and identifying from poultry farms. Next, four strains with the strongest adsorption capacity were used to explore the influence of different physical and chemical factors on the ability of LAB to adsorb Cd as well as its probiotic properties in terms of acid tolerance, bile salt tolerance, drug resistance, and antibacterial effects. Resultantly, the CLF9-1 strain with the best comprehensive ability was selected for further animal protection test. The Cd-tolerant LAB treatment promoted the growth performance of chickens and reduced the Cd-elevated liver and kidney coefficients. Moreover, Cd-induced liver, kidney, and duodenum injuries were alleviated significantly by high-dose LAB treatment. Furthermore, LAB treatment also increased the elimination of Cd in feces and markedly reduced the Cd buildup in the liver and kidney. In summary, these findings determine that screened Cd-tolerant LAB strain exerts a protective effect on chickens against sub-chronic cadmium poisoning, thus providing an essential guideline for the public health and safety of livestock and poultry.