Expanding applications of zeolite imidazolate frameworks in catalysis: synthesis of quinazolines using ZIF-67 as an efficient heterogeneous catalyst

• Published in: RSC advances Vol. 5; no. 31; pp. 24769 - 24776
• Main Authors: Truong, Thanh, Hoang, Tam M., Nguyen, Chung K., Huynh, Quynh T. N., Phan, Nam T. S.
• Format: Journal Article
• Language: English
• Published: 01.01.2015
• Subjects: Catalysts; Cobalt; Derivatives; Optimization; Solvents; Synthesis; Toluene; Zeolites
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/C4RA16168H

A cobalt zeolite imidazolate framework (ZIF-67) was successfully synthesized and characterized by several techniques. The ZIF-67 was used as an efficient heterogeneous catalyst for the cyclization reaction of 2-aminobenzoketones and benzylamine derivatives to form quinazoline products. The optimal conditions involved the use of TBHP oxidant in toluene solvent at 80 °C. Remarkably, the ZIF-67 catalyst exhibited better performance in the cyclization reaction than common cobalt salts such as Co(NO 3 ) 2 , CoCl 2 , and Co(OAc) 2 and other Co-MOFs such as ZIF-9, Co-MOF-74, and Co 2 (BDC) 2 (DABCO). In addition, the cyclization reaction could only proceed in the presence of the solid Co-ZIF catalyst and there was no contribution from leached active sites present in the solution. The catalyst could be recovered and reused several times without a significant degradation in catalytic activity.