Therapeutic Effects of All Trans-retinoitc Acid Combined with Transarterial Chemoembolization on Walker-256 Hepatoma in Rats

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 30; no. 1; pp. 113 - 118
• Main Author: 方建林 郑传胜 陶红芳 赵辉 任建庄 冯敢生
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.02.2010; Department of Radiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan430022,China%Department of Hematology,The first Affiliated Hospital of Shantou Uuniversity Medical College,Shantou 515041,China
• Subjects: Medicine; Medicine & Public Health; induced differentiation; transplanted hepatoma; hepatocarcinoma transarterial chemoembolization; Walker-256 hepatocarcinoma cell; apoptosis; all trans-retinoitc acid; rats
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-010-0121-5

In order to investigate the inhibitory effects of all trans-retinoitc acid(ATRA)on differentiation and apoptosis of Walker-256 hepatocellular carcinoma cells and the therapeutic effects of ATRA combined with transarterial chemoembolization(TACE)on rat Walker-256 transplanted hepatocarcinoma,Walker-256 hepatocarcinoma cell lines were treated with ATRA at different concentrations.After culture for 48h,the inhibitory rate of cell proliferation was determined by MTT assay;the changes of Fas and Bcl-2mRNA expres...