Substantia nigra nigrosome-1 imaging correlates with the severity of motor symptoms in Parkinson's disease

• Published in: Journal of the neurological sciences Vol. 451; p. 120731
• Main Authors: Chu, Yung-Tsai, Yu, Chin-Feng, Fan, Sung-Pin, Chen, Ta-Fu, Chiu, Ming-Jang, Jang, Jyh-Shing Roger, Chiu, Shu-I, Lin, Chin-Hsien
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2023
• Subjects: Humans; Image Processing, Computer-Assisted; Levodopa; Magnetic Resonance Imaging; Parkinson Disease - complications; Substantia Nigra - diagnostic imaging
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/j.jns.2023.120731

Nigrosome-1 imaging has been used for assisting the diagnosis of Parkinson's disease (PD). We aimed to examine the diagnostic performance of loss of nigrosome-1 in PD and the correlation between the size of the nigrosome-1 and motor severity of PD. We included 237 patients with PD and 165 controls. The motor severity of PD was assessed with the Unified Parkinson's Disease Rating Scale (UPDRS) part III score and Hoehn-Yahr staging. The 3 or 1.5 Tesla susceptibility-weighted imaging combined with a deep-learning algorithm was applied for detecting the loss and the size of nigrosome-1. Clinical correlations and diagnostic performance of size of nigrosome-1 were also investigated. The mean nigrosome-1 size was significantly smaller in PD patients than in controls (0.06 ± 0.07 cm2 vs. 0.20 ± 0.05 cm2, P < 0.001). The area under the receiver operating characteristic curve (AUC) of the established model showed 0.94 accuracy (95% confidence interval [CI]: 0.87, 1.01, P < 0.01) in differentiating between the PD and control groups. Moreover, the partial loss of nigrosome-1 detected with SWI had an AUC of 0.96 in discriminating early-stage PD from controls (95% CI: 0.88, 1.02, P < 0.001). After adjusting for age, sex, disease duration, and levodopa equivalent daily dose, the estimated size of nigrosome-1 was negatively associated with the UPDRS part III motor score (ρ = −0.433, P < 0.001), but not with Mini-Mental State Examination scores (ρ = 0.006, P = 0.894). The extent of loss and the size of nigrosome-1 may potentially assist in the diagnosis of PD. Nigrosome-1 size reflects the motor severity of PD. •Loss of nigrosome-1 hyperintensity on susceptibility-weighted imaging assists the diagnosis of Parkinson's disease.•The estimated nigrosome-1 size correlated with motor symptom severity of Parkinson's disease.•CNN-based models using images from clinically feasible brain MRIs assist the diagnosis of Parkinson’s disease.