Density and composition of trabecular and cortical bone in perinatally irradiated Beagles with chronic renal failure

• Published in: Calcified tissue research Vol. 24; no. 1; pp. 99 - 104
• Main Authors: Norrdin, R.W, Phemister, R.D, Jaenke, R.S, Lo-Presti, C.A
• Format: Journal Article
• Language: English
• Published: Germany 14.12.1977
• Subjects: Age Factors; Animals; Bone and Bones - analysis; Calcium - blood; Dogs; Female; hyperparathyroidism; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - pathology; Male; Organ Size; Parathyroid Glands - pathology; Phosphorus - blood; Uremia - metabolism; Water - analysis
• ISSN: 0008-0594
• DOI: 10.1007/BF02223302

Bone density and composition were studied in trabecular and cortical bone from control 2 and 4 year old beagles and those which had various degrees of renal failure as a result of perinatal irradiation. Changes in the two types of bone were qualitatively similar but consistently greater in trabecular bone. In a group identified as markedly uremic, the decrease (P less than 0.025) from control levels in specific gravity was about 4 times greater in trabecular than in cortical samples. The decrease (P less than 0.025) in grams of ash/ml was 9% in trabecular bone and 2% in cortical bone. These changes were associated with an increase (P less than 0.001) in water content and, on a percent by volume basis, approximately equal decreases in ash (P less than 0.025) and combustible matter (P less than 0.025). In a mildly uremic group there were similar trends in mean values but the only significant difference was an increase (P less than 0.001) in trabecular bone water.