Shear-thinning and self-healing chitosan-graphene oxide hydrogel for hemostasis and wound healing

• Published in: Carbohydrate polymers Vol. 294; p. 119824
• Main Authors: Feng, Wenjun, Wang, Zhengke
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 15.10.2022
• Subjects: adhesion; biocompatibility; catalysts; Chitosan; Graphene oxide; heat; Hemostasis; hydrogels; Injectable and self-healing hydrogel; liver; pollutants; rats; synthesis; wastes; Wound healing; Graphene oxide; Wound healing; Chitosan; Hemostasis; Injectable and self-healing hydrogel
• ISSN: 0144-8617; 1879-1344; 1879-1344
• DOI: 10.1016/j.carbpol.2022.119824

Hydrogels with injectability, self-healing ability and adhesiveness have great potential for hemostasis and full-thickness skin wound repair, which are usually fabricated by multistep chemical synthesis and the use of organic solvents and catalyst. Herein, we report an injectable and self-healing hydrogel facilely prepared through one-pot heating of chitosan and graphene oxide mixture solution, without any pollutant and waste generated. The dynamic reversible breakage and recombination of noncovalent bonds between chitosan and graphene oxide endows the hydrogel injectability and self-healing ability. In addition, the mechanical and rheological properties of the hydrogels can be controlled by varying the dosage of graphene oxide. Meanwhile, hydrogels exhibited good adhesiveness and hemocompatibility. Finally, in vivo experiments in a rat liver bleeding model and full-thickness skin defect model verified the outstanding hemostatic and wound healing capability of the hydrogels, indicating the promising future for use as wound dressing. [Display omitted] •CSGO hydrogels are facilely prepared by green fabrication strategy, without any pollutant and waste generated.•Gelation mechanism based on the variations of hydrogen bonds among CS chains and disordering degree of GO is proposed.•CSGO hydrogels have shear-thinning injectable, self-healing and adhesive properties.•CSGO hydrogels possess prominent hemostatic and wound healing capacity, have promising future for use as wound dressings.