A simple and accurate mathematical method for calculation of the EC50

• Published in: Journal of pharmacological and toxicological methods Vol. 41; no. 2-3; pp. 55 - 58
• Main Authors: Alexander, B, Browse, D J, Reading, S J, Benjamin, I S
• Format: Journal Article
• Language: English
• Published: United States 01.04.1999
• Subjects: Animals; Dose-Response Relationship, Drug; Hepatic Artery - metabolism; Humans; Lethal Dose 50; Liver - metabolism; Liver Circulation; Models, Theoretical; Norepinephrine - pharmacokinetics; Perfusion; Rats; Vasoconstrictor Agents - pharmacokinetics

A simple, accurate, and speedy noncomputational technique for the calculation of the EC50 or any other concentration-related parameter of concentration-effect curves is presented. It avoids the necessity for graph construction or computational curve-fitting programs and allows accurate calculation o...