Non-extensive trends in the size distribution of coding and non-coding DNA sequences in the human genome

• Published in: The European physical journal. B, Condensed matter physics Vol. 50; no. 1-2; pp. 259 - 264
• Main Authors: OIKONOMOU, Th, PROVATA, A
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Les Ulis Springer 01.03.2006; Berlin EDP sciences; Springer Nature B.V
• Subjects: Analytical, structural and metabolic biochemistry; Biological and medical sciences; Chromosomes; Decay; Deoxyribonucleic acid; DNA; Exponents; Fundamental and applied biological sciences. Psychology; Gene sequencing; General aspects, investigation methods; Nucleic acids; Distribution function; DNA sequence; Dimension; Genome
• ISSN: 1434-6028; 1434-6036
• DOI: 10.1140/epjb/e2006-00121-2

We study the primary DNA structure of four of the most completely sequenced human chromosomes (including chromosome 19 which is the most dense in coding), using non-extensive statistics. We show that the exponents governing the spatial decay of the coding size distributions vary between 5.2 ≤r ≤5.7 for the short scales and 1.45 ≤q ≤1.50 for the large scales. On the contrary, the exponents governing the spatial decay of the non-coding size distributions in these four chromosomes, take the values 2.4 ≤r ≤3.2 for the short scales and 1.50 ≤q ≤1.72 for the large scales. These results, in particular the values of the tail exponent q, indicate the existence of correlations in the coding and non-coding size distributions with tendency for higher correlations in the non-coding DNA.