Transmembrane ion transport by self-assembling α,γ-peptide nanotubes

In this study, we describe the self-assembling properties of cyclic peptides containing gamma -amino acids in lipid bilayers to form transmembrane nanotubes. The resulting ion channel models are selective for alkaline ions. Although the transport rates conform to the lyotropic series, these partiall...

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Bibliographic Details
Published inChemical science (Cambridge) Vol. 3; no. 11; pp. 3280 - 3285
Main Authors García-Fandiño, Rebeca, Amorín, Manuel, Castedo, Luis, Granja, Juan R.
Format Journal Article
LanguageEnglish
Published 01.11.2012
Subjects
Channels
Ion channels
Ion transport
Lipids
Mathematical models
Nanotubes
Sodium
Transport
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Summary:In this study, we describe the self-assembling properties of cyclic peptides containing gamma -amino acids in lipid bilayers to form transmembrane nanotubes. The resulting ion channel models are selective for alkaline ions. Although the transport rates conform to the lyotropic series, these partially hydrophobic channels show an unexpectedly higher rate for sodium ions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2041-6520
2041-6539
DOI:10.1039/c2sc21068a