Determination of uranium in urine by inductively coupled plasma mass spectrometry with pneumatic nebulization

An analytical method using inductively coupled argon plasma mass spectrometry with pneumatic nebulization sample introduction for the determination of uranium in urine is described. The urine samples were diluted 1+19 (1% HNO sub(3) in Milli-Q water) before analysis. Standard additions calibration w...

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Bibliographic Details
Published inJournal of analytical atomic spectrometry Vol. 13; no. 4; pp. 309 - 313
Main Authors Caddia, Michele, Iversen, Bent Schack
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 1998
Subjects
Analysis of complex biological substances
Analytical, structural and metabolic biochemistry
Argon
Biological and medical sciences
Blood and biological fluids
Body fluids
Fundamental and applied biological sciences. Psychology
Iridium
Mass spectrometry
Plasma applications
Trace analysis
Urine
Actinide
Chemical analysis
Uranium
Coupled method
Pneumatic nebulization
Matrix effect
Inductive coupling plasma spectrometry
Mass spectrometry
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ISSN0267-9477
1364-5544
DOI10.1039/a704444e

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Summary:An analytical method using inductively coupled argon plasma mass spectrometry with pneumatic nebulization sample introduction for the determination of uranium in urine is described. The urine samples were diluted 1+19 (1% HNO sub(3) in Milli-Q water) before analysis. Standard additions calibration with iridium ( super(193)Ir) as an internal standard was used to compensate for undesirable matrix effects. The additions to the diluted samples were 0.1, 0.5, 1.0 and 2.0 ng l super(-1), equivalent to 2, 10, 20 and 40 ng l super(-1) in undiluted urine. The detection limit of the method is 0.32 ng l super(-1), which is sufficiently low to measure uranium in non-exposed subjects. The precision at the 8.9 ng l super(-1) level was 3.9% (RSD), and at the 28.9 ng l super(-1) level 2.0%. The recovery for 20 ng l super(-1) added to ten different samples was 101.5%. Urine samples from 18 non-exposed subjects were analyzed. The mean concentration found was 16.1 ng l super(-1) (median identical with 15.1 ng l super(-1)) with 14.9 ng l super(-1) (median identical with 13.5 ng l super(-1)) for male and 17.2 ng l super(-1) (median identical with 17.6 ng l super(-1)) for female subjects.
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ISSN:0267-9477
1364-5544
DOI:10.1039/a704444e