Preparation and evaluation of blend polymer films for wound dressing using vancomycin-loaded polycaprolactone and carboxymethyl cellulose via crosslinking methods: Effect of mechanical strength, antibacterial activity, and cytotoxicity

Polycaprolactone (PCL) and carboxymethyl cellulose (CMC) are two materials with beneficial properties for wound healing applications. Here, the simple preparation of PCL/CMC polymer films via the crosslinking method was demonstrated for the first time. The polymer films represented the suitable prop...

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Published inJournal of the mechanical behavior of biomedical materials Vol. 151; p. 106339
Main Authors Meedecha, Paweena, Srisang, Naruebodee, Eawsakul, Komgrit, Ongtanasup, Tassanee, Tambunlertchai, Supreeda, Sokjabok, Siwakon, Chungcharoen, Thatchapol, Srisang, Siriwan, Limmun, Warunee
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.2024
Subjects
Carboxymethyl cellulose
Biocompatible
Antimicrobial property
Vancomycin
Polycaprolactone
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Summary:Polycaprolactone (PCL) and carboxymethyl cellulose (CMC) are two materials with beneficial properties for wound healing applications. Here, the simple preparation of PCL/CMC polymer films via the crosslinking method was demonstrated for the first time. The polymer films represented the suitable properties of liquid absorption and tensile strength to be used as a wound dressing. The blend polymer films can also load the vancomycin, which prolongs the drug release for effectiveness against S. aureus. The trifluoroethanol showed less toxicity in comparison with other crosslinking agents. This process can also be applied further in other medical devices and wound healing applications.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1751-6161
1878-0180
DOI:10.1016/j.jmbbm.2023.106339