Lessons Learned from Cancer Metabolism for Physiology and Disease

Tumor cells divide rapidly and dramatically alter their metabolism to meet biosynthetic and bioenergetic needs. Through studying the aberrant metabolism of cancer cells, other contexts in which metabolism drives cell state transitions become apparent. In this work, we will discuss how principles est...

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Published inCold Spring Harbor perspectives in medicine Vol. 15; no. 1; p. a041554
Main Authors Campbell, Sydney L., Christofk, Heather R.
Format Journal Article
LanguageEnglish
Published United States 07.01.2025
Subjects
Animals
Embryonic Development - physiology
Energy Metabolism
Humans
Neoplasms - metabolism
Neoplasms - pathology
Virus Diseases - metabolism
Virus Diseases - pathology
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Summary:Tumor cells divide rapidly and dramatically alter their metabolism to meet biosynthetic and bioenergetic needs. Through studying the aberrant metabolism of cancer cells, other contexts in which metabolism drives cell state transitions become apparent. In this work, we will discuss how principles established by the field of cancer metabolism have led to discoveries in the contexts of physiology and tissue injury, mammalian embryonic development, and virus infection. We present specific examples of findings from each of these fields that have been shaped by the study of cancer metabolism. We also discuss the next important scientific questions facing these subject areas collectively. Altogether, these examples demonstrate that the study of "cancer metabolism" is indeed the study of cell metabolism in the context of a tumor, and undoubtedly discoveries from each of the fields discussed here will continue to build on each other in the future.
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ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a041554