Symptomatic Improvement with Amitriptyline in Ciguatera Fish Poisoning

To the Editor: The clinical syndrome associated with ciguatera fish poisoning has been reviewed previously. The dinoflagellate Gambier-discus toxicus is the implicated source of toxicity. 1 The symptoms associated with ingestion of the toxin are confined to the gastrointestinal, cardiovascular, and...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 315; no. 1; p. 65
Main Authors Davis, R T, Villar, L A
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 03.07.1986
Subjects
Amitriptyline - therapeutic use
Animals
Ciguatera Poisoning
Fishes, Poisonous
Foodborne Diseases - drug therapy
Humans
Hypesthesia - drug therapy
Male
Marine Toxins - poisoning
Middle Aged
Pruritus - drug therapy
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Summary:To the Editor: The clinical syndrome associated with ciguatera fish poisoning has been reviewed previously. The dinoflagellate Gambier-discus toxicus is the implicated source of toxicity. 1 The symptoms associated with ingestion of the toxin are confined to the gastrointestinal, cardiovascular, and nervous systems. 2 The source of ingestion is large fish feeding in tropical reefs. 3 Recently, a 52-year-old man was admitted to our institution after a business trip to the Virgin Islands. Two days before departure from the islands, he dined on a locally caught grouper. Within six hours, he had abdominal cramping and watery diarrhea. Lomotil was prescribed and resulted in . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198607033150115