Clinical observation of ranibizumab combined with surgery in the treatment of neovascular glaucoma with vitreous hemorrhage

• Published in: International ophthalmology Vol. 42; no. 9; pp. 2757 - 2763
• Main Authors: Li, De-Kun, Zhang, Fang, Yu, Jin-Qiang, Liu, Zhen-Kai, Wang, Yan, Mu, Ying-Tao
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.09.2022; Springer Nature B.V
• Subjects: Acuity; Aluminum; Anterior chamber; Exudation; Eye; Eye (anatomy); Glaucoma; Health services; Hemorrhage; Inflammation; Injection; Intraocular pressure; Iris; Levofloxacin; Medicine; Medicine & Public Health; Monoclonal antibodies; Neodymium; Ophthalmology; Original Paper; Patients; Surgery; Vascularization; Visual acuity; Yttrium; Yttrium-aluminum garnet; Trabeculectomy; Vitrectomy; Neovascular glaucoma; Ranibizumab
• ISSN: 1573-2630; 0165-5701; 1573-2630
• DOI: 10.1007/s10792-022-02265-x

Purpose The aim was to explore the clinical efficacy of ranibizumab combined with surgical treatment of neovascular glaucoma with vitreous hemorrhage. Materials and Methods A total of 15 patients (17 affected eyes) who had neovascular glaucoma (NVG) with vitreous hemorrhage in our hospital were enrolled. After admission, the patient was given levofloxacin eye drops, 4 times a day. Three days later, the patients received intravitreal injection of ranibizumab. Then, trabeculectomy and vitrectomy were performed. The detailed clinical data, such as type of diseases, intraocular pressure (IOP), and best corrected visual acuity (BCVA), were collected before and after surgery. Results Visual acuity remained stable or improved in thirteen effected eyes and decreased in effected three eyes. Within 30 days after discharge, one effected eye recurred iris neovascularization with slightly higher IOP; then, the patient received intravitreal injection of ranibizumab again and neodymium-doped yttrium aluminum garnet (YAG) therapy. One patient (one effected eye) was given intravitreal ranibizumab injection again because of uncontrollable IOP and recurrence of neovascularization on iris surface and angle after operation; then, the patient received cyclophotocoagulation. Vitreous cavity hemorrhage occurred again in 3 patients after operation; then, these patients received the vitreous cavity lavage again. After trabeculectomy, inflammatory exudation or a small amount of bleeding could be seen in the anterior chamber of 6 young patients. Conclusion Intravitreal injection of ranibizumab can effectively promote the rapid regression of intraocular neovascularization and help to control the IOP and improve postoperative visual acuity.