The plasma membrane of human erythrocyte with different levels of glucose-6-phosphate dehydrogenase

1. 1. The erythrocyte ghosts from red cells having normal or deficient level of glucose-6-phosphate dehydrogenase have been prepared. 2. 2. The two types of ghosts appear similar in the size and distribution of polypeplides and glyco-proteins. 3. 3. However, chemical modification and fluorescence st...

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Bibliographic Details
Published inInternational journal of biochemistry Vol. 10; no. 4; pp. 361 - 365
Main Author Afolayan, Adeyinka
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 1979
Subjects
Anilino Naphthalenesulfonates - metabolism
Chloroquine - pharmacology
Erythrocyte Membrane - analysis
Erythrocyte Membrane - drug effects
Erythrocyte Membrane - metabolism
Erythrocytes - drug effects
Fluorescence
Glucosephosphate Dehydrogenase Deficiency - blood
Glycoproteins - analysis
Membrane Proteins - analysis
Peptides - analysis
Primaquine - pharmacology
Trinitrobenzenesulfonic Acid - metabolism
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Summary:1. 1. The erythrocyte ghosts from red cells having normal or deficient level of glucose-6-phosphate dehydrogenase have been prepared. 2. 2. The two types of ghosts appear similar in the size and distribution of polypeplides and glyco-proteins. 3. 3. However, chemical modification and fluorescence studies in the presence of primaquine and chloroquine suggest a possible difference in structure between the two types of ghost. 4. 4. Generally, the ghost from red cell with defficient G6PD is more perturbed by antimalarial drugs. 5. 5. This result may explain why carriers of this deficient enzyme have their red cells readily haemolysed on consumption of antimalarial drugs.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0020-711X
DOI:10.1016/0020-711X(79)90101-0