Therapeutic Strategies for Drug-resistant Melanoma and Their Clinical Implications

Melanoma is a malignant tumor originating from melanocytes, characterized by its high invasiveness and metastasis, leading to poor prognosis and high mortality. Early-stage melanoma is primarily treated with surgery; however, due to its metastatic nature, surgery becomes challenging in advanced stag...

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Bibliographic Details
Published inJournal of cancer prevention Vol. 30; no. 1; pp. 7 - 11
Main Authors Huang, Ke, Kim, Myoung Ok
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society of Cancer Prevention 30.03.2025
대한암예방학회
Subjects
Review
예방의학
Molecular targeted therapy
Proto-oncogene proteins B-raf
neoplasm
Drug resistance
Melanoma
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ISSN2288-3649
2288-3657
DOI10.15430/JCP.24.028

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Summary:Melanoma is a malignant tumor originating from melanocytes, characterized by its high invasiveness and metastasis, leading to poor prognosis and high mortality. Early-stage melanoma is primarily treated with surgery; however, due to its metastatic nature, surgery becomes challenging in advanced stages. Treatment strategies for advanced or metastatic melanoma include chemotherapy, radiation therapy, and targeted therapy. However, melanoma's propensity for rapid drug resistance remains a significant clinical challenge. This review summarizes the developments in the treatment of drug-resistant melanoma over the past decade and discusses the advantages and disadvantages of various therapeutic approaches and their clinical significance implications.
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https://doi.org/10.15430/JCP.24.028
ISSN:2288-3649
2288-3657
DOI:10.15430/JCP.24.028