Autologous platelet concentrates in extraction sockets for the prevention of osteoradionecrosis: a systematic review of controlled clinical trials

• Published in: Oral and maxillofacial surgery Vol. 26; no. 4; pp. 555 - 561
• Main Authors: Serrano, Rafael Verardi, Gomes, Thiago Pallin, da Silva, Felipe Medeiros, Chambrone, Leandro, Marques, Marcia Martins, Palma, Luiz Felipe
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2022; Springer Nature B.V
• Subjects: Bias; Blood platelets; Clinical trials; Dentistry; Growth factors; Head & neck cancer; Maxillofacial surgery; Medicine; Medicine & Public Health; Oral and Maxillofacial Surgery; Plasma; Prevention; Radiation therapy; Review Article; Systematic review; Extraction; Platelet-rich fibrin; Radiotherapy; Platelet-rich plasma; Osteoradionecrosis
• ISSN: 1865-1569; 1865-1550; 1865-1569
• DOI: 10.1007/s10006-021-01030-1

This systematic review aimed to assess whether the use of autologous platelet concentrates immediately after tooth extraction would prevent ORN in patients treated with radiotherapy (RT) for head and neck cancer (HNC). MEDLINE, Embase, Ovid, Scopus, Web of Science, CENTRAL Cochrane, and OpenGrey databases were searched (up to, and including, June 2021) by two independent reviewers to identify studies, followed by further manual search. As inclusion and exclusion criteria for the studies, only controlled clinical trials (randomized or not) were considered. The risk of bias of each included study was assessed using the Cochrane Risk of Bias Tool. Of the 129 potentially eligible studies, only 2 were included, both randomized controlled clinical trials; however, one used platelet-rich plasma and another leukocyte- and platelet-rich fibrin. Overall, both autologous platelet concentrates had no effect on the outcome assessed. The use of autologous platelet concentrates seems not to be beneficial for ORN prevention following tooth extractions in HNC patients treated with RT; however, according to the available evidence, a reliable statement cannot be made.