Cytogenetic investigation in Iranian patients suspected with Fanconi anemia

We present our study on 318 patients suspected with Fanconi anemia (FA) referred to The Iranian Blood Transfusion Organization during the period of 4 years. Mitomycin C (MMC) was used as a DNA cross-linker to study chromosomal breakage. In total 61 positive cases were diagnosed cytogenetically. The...

Full description

Saved in:
Bibliographic Details
Published inJournal of pediatric hematology/oncology Vol. 28; no. 12; p. 834
Main Authors Tootian, Sameeramis, Mahjoubi, Frouzandeh, Rahnama, Mitra, Hormozian, Fabyola, Mortezapour, Farzaneh, Razazian, Faegeh, Manoochehri, Farnoosh, Zamanian, Mahsa, Nasiri, Fatemeh, Soleymani, Saeedeh, Seyedmortaz, Ladan
Format Journal Article
LanguageEnglish
Published United States 01.12.2006
Subjects
Chromosome Breakage - drug effects
Cytogenetics - methods
Fanconi Anemia - diagnosis
Fanconi Anemia - genetics
Female
Humans
Iran
Male
Mitomycin - pharmacology
Nucleic Acid Synthesis Inhibitors - pharmacology
Retrospective Studies
Iran
Online AccessGet more information

Cover

More Information
Summary:We present our study on 318 patients suspected with Fanconi anemia (FA) referred to The Iranian Blood Transfusion Organization during the period of 4 years. Mitomycin C (MMC) was used as a DNA cross-linker to study chromosomal breakage. In total 61 positive cases were diagnosed cytogenetically. The ratio of women being affected was slightly higher than men. Comparison of several hematologic and clinical parameters in FA (MMC positive) and non-FA (MMC negative) patients showed no clinically significant differences. This study also indicates that this sort of test is very useful and essential for accurate diagnosis of patients with FA with or without congenital anomalies.
ISSN:1077-4114
DOI:10.1097/MPH.0b013e31802d3e1d