Antioxidative Effects of Choi-joki-to and its Ability to Inhibit the Progression of Atheroma in KHC Rabbits

Agents which inhibit the oxidative modification of low density lipoprotein (LDL) have been thought to be helpful in preventing the formation of atherosclerotic lesions ; the so-called “oxidation hypothesis”. To test this hypothesis, we examined the antioxidative activities of 127 Kampo medicines in...

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Bibliographic Details
Published inJournal of Atherosclerosis and Thrombosis Vol. 6; no. 2; pp. 49 - 54
Main Authors Iizuka, Akira, Iijima, Osamu T., Kondo, Kazuo, Matsumoto, Akiyo, Itakura, Hiroshige, Yoshie, Fumihiko, Komatsu, Yasuhiro, Takeda, Hiroshi, Matsumiya, Teruhiko
Format Journal Article
LanguageEnglish
Published Japan Atherosclerosis Society 2000
Subjects
Antioxidation
Choi-joki-to
KHC rabbits
Low density lipoprotein
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Summary:Agents which inhibit the oxidative modification of low density lipoprotein (LDL) have been thought to be helpful in preventing the formation of atherosclerotic lesions ; the so-called “oxidation hypothesis”. To test this hypothesis, we examined the antioxidative activities of 127 Kampo medicines in vitro and their inhibitory effects on the development of atheromatous plaque formation in KHC rabbits, a model of spontaneous familial hypercholesterolemia. Some of the 127 Kampo medicines showed scavenging or antioxidative effects equal to or stronger than those of probucol in vitro. Choi-joki-to, which had the strongest antioxidative effects on LDL in vitro, was chosen for a study in vivo. After 24 weeks, 1 g/kg of Choi-joki-to successfully inhibited the progression of atherosclerotic lesions in KHC rabbits (P<0.01). Further investigations regarding the antioxidative effects of Kampo medicines are expected.
ISSN:1340-3478
1880-3873
DOI:10.5551/jat1994.6.49