Fatal 4-MEC Intoxication: Case Report and Review of Literature

• Published in: The American journal of forensic medicine and pathology Vol. 42; no. 1; p. 57
• Main Authors: Braham, Mohamed Yassine, Franchi, Angélique, Cartiser, Nathalie, Bévalot, Fabien, Bottinelli, Charline, Fabrizi, Hervé, Fanton, Laurent
• Format: Journal Article
• Language: English
• Published: United States 01.03.2021
• ISSN: 1533-404X
• DOI: 10.1097/PAF.0000000000000599

Synthetic cathinones are one of the major pharmacological families of new psychoactive substances and 4-methylethcathinone (4-MEC) has emerged in recent years as a recreational psychostimulant. We report a case of a 35-year-old man found dead and naked at home by his friend. Although no anatomic cause of death was observed at autopsy, toxicological analysis identified 4-MEC and hydroxyzine at therapeutic level (160 ng/mL). 4-Methylethcathinone was quantified in autopsy samples by a validated method consisting in liquid-liquid extraction and gas chromatography coupled to tandem mass spectrometry: peripheral blood, 14.6 μg/mL; cardiac blood, 43.4 μg/mL; urine, 619 μg/mL; vitreous humor, right 2.9 μg/mL and left 4.4 μg/mL; bile, 43.5 μg/mL; and gastric content, 28.2 μg/mL. The cause of death was 4-MEC intoxication and the manner of death could be either accidental or suicidal. The literature concerning 4-MEC was reviewed, focusing on distribution in classical postmortem matrices and 4-MEC metabolism and postmortem redistribution and stability.