Interferon-γ and atherosclerosis : Pro- or anti-atherogenic?
Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-...
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Published in | Cardiovascular research Vol. 67; no. 1; pp. 11 - 20 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Oxford
Oxford University Press
01.07.2005
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Subjects | |
Online Access | Get full text |
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Summary: | Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the function and properties of all the cell types in the vessel wall. The precise role of IFN-gamma in atherogenesis is complex, with both pro- and anti-atherogenic actions being identified. This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN-gamma signaling. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0008-6363 1755-3245 |
DOI: | 10.1016/j.cardiores.2005.04.019 |