BIA–MS–MS: biomolecular interaction analysis for functional proteomics

• Published in: Trends in Biotechnology Vol. 19; no. 10 Suppl; pp. 28 - 33
• Main Authors: Natsume, Tohru, Nakayama, Hiroshi, Isobe, Toshiaki
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.2001
• Subjects: biomolecular interaction analysis; Biosensing Techniques; functional proteomics; MALDI-TOF; mass spectrometry; Mass Spectrometry - methods; Molecular Biology - methods; Protein Interaction Mapping; Proteins - chemistry; Proteins - metabolism; proteomics; Sequence Analysis, Protein - methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods; Surface Plasmon Resonance; Two-Hybrid System Techniques; Biotechnology; MALDI-TOF; Techniques & Methods; surface plasmon resonance; functional proteomics; biomolecular interaction analysis; mass spectrometry; Drug Discovery

One of the experimental processes of functional proteomics is the analysis of protein interaction. Here, we review a new analytical platform, BIA–MS, for protein interaction analysis. BIA–MS is an integration of a surface plasmon resonance biosensor for real-time interaction analysis and mass spectr...