BIA–MS–MS: biomolecular interaction analysis for functional proteomics

One of the experimental processes of functional proteomics is the analysis of protein interaction. Here, we review a new analytical platform, BIA–MS, for protein interaction analysis. BIA–MS is an integration of a surface plasmon resonance biosensor for real-time interaction analysis and mass spectr...

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Bibliographic Details
Published inTrends in Biotechnology Vol. 19; no. 10 Suppl; pp. 28 - 33
Main Authors Natsume, Tohru, Nakayama, Hiroshi, Isobe, Toshiaki
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2001
Subjects
biomolecular interaction analysis
Biosensing Techniques
functional proteomics
MALDI-TOF
mass spectrometry
Mass Spectrometry - methods
Molecular Biology - methods
Protein Interaction Mapping
Proteins - chemistry
Proteins - metabolism
proteomics
Sequence Analysis, Protein - methods
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - instrumentation
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
Surface Plasmon Resonance
Two-Hybrid System Techniques
Biotechnology
MALDI-TOF
Techniques & Methods
surface plasmon resonance
functional proteomics
biomolecular interaction analysis
mass spectrometry
Drug Discovery
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Summary:One of the experimental processes of functional proteomics is the analysis of protein interaction. Here, we review a new analytical platform, BIA–MS, for protein interaction analysis. BIA–MS is an integration of a surface plasmon resonance biosensor for real-time interaction analysis and mass spectrometry for the subsequent identification of interacting molecules.
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ISSN:0167-7799
1879-3096
DOI:10.1016/S0167-7799(01)00006-3