Outpatient Laboratory Monitoring for Antibiotic-related Adverse Events in Children With Acute Hematogenous Osteomyelitis

• Published in: The Pediatric infectious disease journal Vol. 44; no. 3; p. e74
• Main Authors: Rosiji, Felicia O, Joseph, Marritta, Sommer, Lauren M, Kaplan, Sheldon L, Vallejo, Jesus G, McNeil, J Chase
• Format: Journal Article
• Language: English
• Published: United States 01.03.2025
• Subjects: Adolescent; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - therapeutic use; Child; Child, Preschool; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions - diagnosis; Drug-Related Side Effects and Adverse Reactions - epidemiology; Female; Humans; Infant; Male; Osteomyelitis - drug therapy; Outpatients

Monitoring for antibiotic-related lab abnormalities (ARLA), including hematologic, renal, and/or hepatic toxicity, in pediatric osteomyelitis is common. In 240 cases of osteomyelitis with outpatient laboratory monitoring, ARLA occurred in 13.3% with the most common finding being neutropenia. ARLA im...