Outpatient Laboratory Monitoring for Antibiotic-related Adverse Events in Children With Acute Hematogenous Osteomyelitis

Monitoring for antibiotic-related lab abnormalities (ARLA), including hematologic, renal, and/or hepatic toxicity, in pediatric osteomyelitis is common. In 240 cases of osteomyelitis with outpatient laboratory monitoring, ARLA occurred in 13.3% with the most common finding being neutropenia. ARLA im...

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Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 44; no. 3; p. e74
Main Authors Rosiji, Felicia O, Joseph, Marritta, Sommer, Lauren M, Kaplan, Sheldon L, Vallejo, Jesus G, McNeil, J Chase
Format Journal Article
LanguageEnglish
Published United States 01.03.2025
Subjects
Adolescent
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - therapeutic use
Child
Child, Preschool
Drug Monitoring
Drug-Related Side Effects and Adverse Reactions - diagnosis
Drug-Related Side Effects and Adverse Reactions - epidemiology
Female
Humans
Infant
Male
Osteomyelitis - drug therapy
Outpatients
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Summary:Monitoring for antibiotic-related lab abnormalities (ARLA), including hematologic, renal, and/or hepatic toxicity, in pediatric osteomyelitis is common. In 240 cases of osteomyelitis with outpatient laboratory monitoring, ARLA occurred in 13.3% with the most common finding being neutropenia. ARLA impacted antibiotic therapy in <1% of subjects, however, raising questions about the value of such monitoring being performed routinely.
ISSN:1532-0987
DOI:10.1097/INF.0000000000004576