Can systems immunology lead tuberculosis eradication?

25 years after the declaration of a Global Emergency by the World Health Organization, tuberculosis (TB) remains a major enemy to the humankind. During this period, much progress has been done to better understand its natural history, revealing its huge complexity, which highlighted the need for imp...

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Published inCurrent opinion in systems biology Vol. 12; pp. 53 - 60
Main Authors Cardona, Pere-Joan, Català, Martí, Arch, Marta, Arias, Lilibeth, Alonso, Sergio, Cardona, Paula, López, Daniel, Vilaplana, Cristina, Prats, Clara
Format Journal Article Publication
LanguageEnglish
Published Elsevier Ltd 01.12.2018
Elsevier
Subjects
Agent-based model
Granuloma
Matemàtica aplicada a les ciències
Matemàtiques i estadística
Mathematical model
Mathematical models
Models matemàtics
Systems biology
Systems immunology
Tuberculosi
Tuberculosis
Àrees temàtiques de la UPC
Systems immunology
Granuloma
Tuberculosis
Mathematical model
Systems biology
Agent-based model
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Summary:25 years after the declaration of a Global Emergency by the World Health Organization, tuberculosis (TB) remains a major enemy to the humankind. During this period, much progress has been done to better understand its natural history, revealing its huge complexity, which highlighted the need for implementing systems immunology approaches. Recent advances focused in understanding the role of macrophage subtypes and dendritic cells role, the importance of cytokine balance, and the antigenic repertoire. Identification of early irruption of polymorphonuclear neutrophils and extracellular growth of the bacilli seem to be the most disruptive factors to understand the evolution towards active TB. Their inclusion in future models will provide new tools for the better understanding of the tuberculosis.
ISSN:2452-3100
2452-3100
DOI:10.1016/j.coisb.2018.10.004