Layer-by-Layer Coated PLA Nanoparticles with Oppositely Charged β-Cyclodextrin Polymer for Controlled Delivery of Lipophilic Molecules

• Published in: Macromolecular chemistry and physics Vol. 215; no. 6; pp. 555 - 565
• Main Authors: El Fagui, Amani, Wintgens, Véronique, Gaillet, Christine, Dubot, Pierre, Amiel, Catherine
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.03.2014; Wiley
• Subjects: anionic β-cyclodextrin polymers; Applied sciences; Biological and medical sciences; cationic β-cyclodextrin polymers; Charging; controlled release; Drugs; Electrostatics; Exact sciences and technology; Forms of application and semi-finished materials; General pharmacology; Holes; layer-by-layer assembly; Light scattering; Medical sciences; Miscellaneous; Multilayers; Nanoparticles; Nanostructure; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; poly(lactic acid) (PLA) nanoparticles; Polymer industry, paints, wood; Surface chemistry; Technology of polymers; Self-assembled layer; Self assembly; Hydrodynamic radius; Nanoparticle; cationic β-cyclodextrin polymers; Drug carrier; Benzophenone; Coated particle; Electrokinetic potential; anionic β-cyclodextrin polymers; Manufacturing; Release; poly(lactic acid) (PLA) nanoparticles; Control release polymer; Multiple layer; Hydrophobic compound; Experimental study; Polyelectrolyte; Sulfonate polymer; Cyclodextrin; Lactic acid polymer; controlled release; Oside polymer; layer-by-layer assembly; Kinetics; Quaternary ammonium polymer

The preparation of novel nanoparticles is described, which consist of a poly(lactic acid) (PLA) core obtained by the nanoprecipitation method with a shell made of oppositely charged β‐cyclodextrin polymer (poly‐β‐CD) assembled using the layer‐by‐layer technique. Characterization of these nanoparticl...