Layer-by-Layer Coated PLA Nanoparticles with Oppositely Charged β-Cyclodextrin Polymer for Controlled Delivery of Lipophilic Molecules

• Published in: Macromolecular chemistry and physics Vol. 215; no. 6; pp. 555 - 565
• Main Authors: El Fagui, Amani, Wintgens, Véronique, Gaillet, Christine, Dubot, Pierre, Amiel, Catherine
• Format: Journal Article
• Language: English
• Published: Weinheim Blackwell Publishing Ltd 01.03.2014; Wiley
• Subjects: anionic β-cyclodextrin polymers; Applied sciences; Biological and medical sciences; cationic β-cyclodextrin polymers; Charging; controlled release; Drugs; Electrostatics; Exact sciences and technology; Forms of application and semi-finished materials; General pharmacology; Holes; layer-by-layer assembly; Light scattering; Medical sciences; Miscellaneous; Multilayers; Nanoparticles; Nanostructure; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; poly(lactic acid) (PLA) nanoparticles; Polymer industry, paints, wood; Surface chemistry; Technology of polymers; Self-assembled layer; Self assembly; Hydrodynamic radius; Nanoparticle; cationic β-cyclodextrin polymers; Drug carrier; Benzophenone; Coated particle; Electrokinetic potential; anionic β-cyclodextrin polymers; Manufacturing; Release; poly(lactic acid) (PLA) nanoparticles; Control release polymer; Multiple layer; Hydrophobic compound; Experimental study; Polyelectrolyte; Sulfonate polymer; Cyclodextrin; Lactic acid polymer; controlled release; Oside polymer; layer-by-layer assembly; Kinetics; Quaternary ammonium polymer
• ISSN: 1022-1352; 1521-3935
• DOI: 10.1002/macp.201300693

The preparation of novel nanoparticles is described, which consist of a poly(lactic acid) (PLA) core obtained by the nanoprecipitation method with a shell made of oppositely charged β‐cyclodextrin polymer (poly‐β‐CD) assembled using the layer‐by‐layer technique. Characterization of these nanoparticles is accomplished through dynamic light scattering, ζ‐potential measurements, X‐ray photoelectron spectroscopy and electron microscopy. The release of a loaded lipophilic molecule, benzophenone (BP), is mainly controlled by diffusion of BP and by its host–guest interaction with the β‐CD cavities of the adsorbed poly‐β‐CD. Increasing the number of poly‐β‐CD layers results in a better control of the release through the partition equilibrium between free BP and BP included in the cavities inside the multilayers. A layer‐by‐layer adsorption process driven by electrostatic interactions is accomplished at the surface of poly(lactic acid) nanoparticles with oppositely charged β‐cyclodextrin polymers. The growth of the multilayer is monitored by complementary techniques. Benzophenone, a lipophilic molecule, is incorporated, and its release is also investigated. The nanoparticles have potential use as controlled assembly and release materials for some lipophilic drugs.