Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals

Multiple Omicron sub-lineages have emerged, with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this study. The key feature of new variants is their ability to escape humoral immunity despite the fact that there are limited genetic changes from their prece...

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Published inhLife Vol. 1; no. 1; pp. 26 - 34
Main Authors Tan, Chee Wah, Zhu, Feng, Chia, Wan Ni, Young, Barnaby E, Yeoh, Aileen Ying Yan, Althaus, Thomas, Yung, Chee Fu, Yap, Wee Chee, Lim, Beng Lee, Chen, Mark I-C, Zhang, Jinyan, Mah, Yun Yan, Voiglio, Eric, Sigal, Alex, Huo, Jianxin, Xu, Shengli, Tan, Yee Joo, Lam, Kong-Peng, Lye, David, Wang, Lin-Fa
Format Journal Article
LanguageEnglish
Published Netherlands 01.11.2023
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Summary:Multiple Omicron sub-lineages have emerged, with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this study. The key feature of new variants is their ability to escape humoral immunity despite the fact that there are limited genetic changes from their preceding variants. This raises the question of whether Omicron should be regarded as a separate serotype from viruses serologically clustered with the ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Here, we present cross-neutralization data based on a pseudovirus neutralization test using convalescent sera from naïve individuals who had recovered from primary infection by SARS-CoV-1 and SARS-CoV-2 strains/variants including the ancestral virus and variants Beta, Delta, Omicron BA.1, Omicron BA.2 and Omicron BA.5. The results revealed no significant cross-neutralization in any of the three-way testing for SARS-CoV-1, ancestral SARS-CoV-2 and SARS-CoV-2 Omicron subvariants. The data argue for the assignment of three distinct serotypes for the currently known human-infecting SARS-related coronaviruses.
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ISSN:2949-9283
2949-9283
DOI:10.1016/j.hlife.2023.07.002