FDG PET/CT in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma

Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin's lymphoma, with rearrangements of the anaplastic lymphoma kinase gene in 60%-85% of systemic cases. We report an 11-year-old boy with ALCL in whom serial FDG PET/CT revealed partial response and complete metabolic response at interim...

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Bibliographic Details
Published inClinical nuclear medicine Vol. 45; no. 7; p. 540
Main Authors Angamuthu, Meivel, Kaur, Kanwaljeet, Tripathi, Madhavi, Meena, Jagdish Prasad, Seth, Rachna, Kumar, Rakesh
Format Journal Article
LanguageEnglish
Published United States 01.07.2020
Subjects
Anaplastic Lymphoma Kinase - metabolism
Child
Fluorodeoxyglucose F18
Humans
Lymphoma, Large-Cell, Anaplastic - diagnostic imaging
Lymphoma, Large-Cell, Anaplastic - enzymology
Male
Positron Emission Tomography Computed Tomography
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Summary:Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin's lymphoma, with rearrangements of the anaplastic lymphoma kinase gene in 60%-85% of systemic cases. We report an 11-year-old boy with ALCL in whom serial FDG PET/CT revealed partial response and complete metabolic response at interim and end of treatment, respectively. However, the patient relapsed within 2 weeks, confirmed by cytology. Because of the inherent aggressive nature of ALCL, possibility of an early relapse should always be kept in mind.
ISSN:1536-0229
DOI:10.1097/RLU.0000000000003071