Vulvar Myxoid Liposarcoma and Well Differentiated Liposarcoma With Molecular Cytogenetic Confirmation: Case Reports With Review of Malignant Lipomatous Tumors of the Vulva

Malignant lipomatous tumors of the vulva are uncommon. We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hyb...

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Bibliographic Details
Published inInternational journal of gynecological pathology Vol. 34; no. 4; p. 390
Main Authors Schoolmeester, John Kenneth, Leifer, Aaron J, Wang, Lu, Hameed, Meera R
Format Journal Article
LanguageEnglish
Published United States 01.07.2015
Subjects
Adult
Aged
Cytogenetics
Female
Gene Rearrangement
Humans
In Situ Hybridization, Fluorescence
Lipoma - genetics
Lipoma - pathology
Liposarcoma, Myxoid - genetics
Liposarcoma, Myxoid - pathology
Proto-Oncogene Proteins c-mdm2 - genetics
RNA-Binding Protein FUS - genetics
Transcription Factor CHOP - genetics
Vulva - pathology
Vulvar Neoplasms - genetics
Vulvar Neoplasms - pathology
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Summary:Malignant lipomatous tumors of the vulva are uncommon. We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hybridization. Both cases are the first liposarcomas of this site to be confirmed by molecular cytogenetic analysis. We also review the literature's cases of liposarcoma to further examine the clinicopathologic features of these tumors.
ISSN:1538-7151
DOI:10.1097/PGP.0000000000000170