Polymorphic markers of the NO synthase genes and genetic predisposition to diabetic polyneuropathy in type 1 diabetes mellitus

• Published in: Molecular biology (New York) Vol. 39; no. 2; pp. 200 - 205
• Main Authors: Zotova, E. V., Voron’ko, O. E., Bursa, T. R., Galeev, I. V., Strokov, I. A., Nosikov, V. V.
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.03.2005
• Subjects: Diabetes; Genes; Genetics
• ISSN: 0026-8933; 1608-3245
• DOI: 10.1007/s11008-005-0029-5

The allele and genotype frequency distributions of polymorphic markers of the NOS1, NOS2, and NOS3 genes coding for three different NO synthases were compared for type 1 diabetes mellitus (T1DM) patients with or without diabetic polyneuropathy (DPN). The groups (total 180 patients, ethnic Russians or East Slavs from Moscow) had nonoverlapping (polar) phenotypes. Group DPN+ included patients with DPN and T1DM duration of no more than 5 years. Control group DPN- included patients without DPN and with T1DM duration of at least 10 years. No significant differences in allele and genotype frequency distributions were revealed for the polymorphic markers (CA)^sub n^ of gene NOS1 (CCTTT)^sub n^ of gene NOS2, and ecNOS4a/4b and Glu298Asp of gene NOS3, suggesting a lack of association between the polymorphic markers and DPN. In the case of the (CCTTT)^sub n^ polymorphic marker of the NOS2 gene, a tendency toward an association with DPN was observed for allele 14. Carriers of this allele have a lower risk of DPN in T1DM.[PUBLICATION ABSTRACT]