An expedient one-pot synthesis for protected 2-thia-5-azabicyclo[2.2.1]heptan-3-ones. Versatile intermediates in the synthesis of carbapenem sidechains

A convenient and high yielding one-pot process for the preparation of protected 2-thia-5-azabicyclo-[2.2.1]heptan-3-ones from 4-hydroxyproline and their use in the synthesis of carbapenem sidechains is described. Graphic

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Bibliographic Details
Published inTetrahedron letters Vol. 37; no. 17; pp. 2919 - 2922
Main Authors Brands, K.M.J., Marchesini, G., Williams, J.M., Dolling, U.-H., Reider, P.J.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 22.04.1996
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
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Summary:A convenient and high yielding one-pot process for the preparation of protected 2-thia-5-azabicyclo-[2.2.1]heptan-3-ones from 4-hydroxyproline and their use in the synthesis of carbapenem sidechains is described. Graphic
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(96)00447-9