Design and synthesis of novel functional lipid-based bioconjugates for drug delivery and other applications

The modification of biologicals such as proteins/peptides, small molecules, and other polymers with lipids provides an efficient method for mediating their insertion into liposomes and lipid-core micellar nanocarriers. In this chapter, we describe several representative protocols developed in our la...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 751; p. 357
Main Authors Sawant, Rupa R, Torchilin, Vladimir P
Format Journal Article
LanguageEnglish
Published United States 2011
Subjects
Amino Acid Sequence
Antibodies, Monoclonal - chemistry
Ascorbic Acid - chemistry
Chelating Agents - chemistry
DNA - chemistry
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drug Design
Drug Stability
Gene Products, tat - chemistry
Hydrophobic and Hydrophilic Interactions
Lipids - chemistry
Liposomes - chemistry
Magnetic Resonance Imaging
Micelles
Molecular Imaging
Nanostructures - chemistry
Pentetic Acid - chemistry
Phosphatidylethanolamines - chemistry
Polyethylene Glycols - chemistry
Polyethyleneimine - chemistry
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Summary:The modification of biologicals such as proteins/peptides, small molecules, and other polymers with lipids provides an efficient method for mediating their insertion into liposomes and lipid-core micellar nanocarriers. In this chapter, we describe several representative protocols developed in our laboratory for the bioconjugation of liposomes and lipid-core micelles for drug/gene delivery and diagnostic imaging applications.
ISSN:1940-6029
DOI:10.1007/978-1-61779-151-2_23