Changes in the rate of lipid peroxidation in plasma and selected blood antioxidants before and during pregnancy in ewes

• Published in: Acta veterinaria Brno Vol. 78; no. 2; pp. 237 - 242
• Main Authors: Erisir, M.,Firat Univ., Elazig (Turkey). Dept. of Biochemistry, Benzer, F.,Veterinary Control and Research Inst., Elazig (Turkey), Kandemir, F.M.,Firat Univ., Elazig (Turkey). Dept. of Biochemistry
• Format: Journal Article
• Language: English
• Published: 01.06.2009
• Subjects: ACTIVIDAD ENZIMATICA; ACTIVITE ENZYMATIQUE; BELIER; BREBIS; CATALASA; CATALASE; ENZYME ACTIVITY; ESTRES; EWES; GESTACION; GESTATION; GLUTACION; GLUTATHION; GLUTATHION PEROXYDASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATION PEROXIDASA; http://www.fao.org/aos/agrovoc#c_11184; http://www.fao.org/aos/agrovoc#c_1380; http://www.fao.org/aos/agrovoc#c_2604; http://www.fao.org/aos/agrovoc#c_2746; http://www.fao.org/aos/agrovoc#c_29508; http://www.fao.org/aos/agrovoc#c_5472; http://www.fao.org/aos/agrovoc#c_6166; http://www.fao.org/aos/agrovoc#c_6443; http://www.fao.org/aos/agrovoc#c_7030; http://www.fao.org/aos/agrovoc#c_7452; MALONDIALDEHYDE; MORUECO; OVEJA; OVIN; OVINOS; OXIDACION; OXIDATION; OXYDATION; PREGNANCY; RAMS; SHEEP; STRESS
• ISSN: 0001-7213; 1801-7576
• DOI: 10.2754/avb200978020237

Pregnancy is a condition that favours oxidative stress. The aim of this study was to evaluate the oxidant and antioxidant status by measuring glutathione peroxidase (GSH-Px), catalase (CAT) activities, and malondialdehyde (MDA) and glutathione (GSH) concentrations before and during pregnancy in ewes. Twelve healthy female and two healthy male Awassi sheep (4-5 years old, 50-55 kg) were used. The ewes' blood samples were taken before synchronization and during pregnancy (on 25th days of each month of pregnancy). Plasma MDA concentrations in the 2nd and 3rd months of pregnancy in ewes were lower than in the 1st, 4th, 5th months of pregnancy and in the non-pregnant ewes. GSH concentrations and GSH-Px activities during pregnancy were increased (P less than 0.01). GSH concentrations and GSH-Px activities were the highest in the 2nd and 3rd months of pregnancy. CAT activities were decreased after the 1st month of pregnancy in ewes (P less than 0.001). They were the lowest in the 2nd and 3rd months of pregnancy. The findings of our study show decreased CAT activities and elevated GSH concentrations and GSH-Px activities after the 1st month of pregnancy. These changes in the indicators under study may indicate a predisposition to oxidative stress in the 2nd and 3rd month of pregnancy in ewes.