Polyketide origin of 3-alkylpyridines in the marine mollusc Haminoea orbignyana

Graphic The paper reports the biosynthesis of the main alkylpyridine alkaloids, haminol-1 ( 1 ) and -2 ( 2 ), in the Mediterranean mollusc Haminoea orbignyana. Experiments were carried out by in vivo incorporation of [1,2- 13C 2 acetate]. Data give full account for a polyketide origin of haminols in...

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Published inTetrahedron letters Vol. 45; no. 12; pp. 2627 - 2629
Main Authors Cutignano, Adele, Cimino, Guido, Giordano, Antonella, d’Ippolito, Giuliana, Fontana, Angelo
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 15.03.2004
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Summary:Graphic The paper reports the biosynthesis of the main alkylpyridine alkaloids, haminol-1 ( 1 ) and -2 ( 2 ), in the Mediterranean mollusc Haminoea orbignyana. Experiments were carried out by in vivo incorporation of [1,2- 13C 2 acetate]. Data give full account for a polyketide origin of haminols in the Mediterranean molluscs, showing the biosynthesis of these 3-alkylpyridine alkaloids by elongation with acetate of a starter unit of nicotinic acid.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2004.01.138