Enzymatic desymmetrization of meso(anti-anti)-2,4-dimethyl-1,3,5-pentanetriol

• Published in: Tetrahedron: asymmetry Vol. 6; no. 9; pp. 2093 - 2096
• Main Authors: Chênevert, Robert, Courchesne, Gabriel
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.09.1995; Elsevier
• Subjects: Chemistry; Chemistry, Inorganic & Nuclear; Chemistry, Organic; Chemistry, Physical; Physical Sciences; Science & Technology; DERIVATIVES; METABOLITES

The stereoselective acetylation of meso-3-( tert-butyldimethylsiloxy)-2,4-dimethyl-1,5-pentanediol by vinyl acetate in the presence of Candida rugosa lipase in organic medium gave the corresponding (2R, 3R, 4S) mono ester in high enantiomeric purity (ee = 97%). Graphic