Enzymatic desymmetrization of meso(anti-anti)-2,4-dimethyl-1,3,5-pentanetriol

The stereoselective acetylation of meso-3-( tert-butyldimethylsiloxy)-2,4-dimethyl-1,5-pentanediol by vinyl acetate in the presence of Candida rugosa lipase in organic medium gave the corresponding (2R, 3R, 4S) mono ester in high enantiomeric purity (ee = 97%). Graphic

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 6; no. 9; pp. 2093 - 2096
Main Authors Chênevert, Robert, Courchesne, Gabriel
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 01.09.1995
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
DERIVATIVES
METABOLITES
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Summary:The stereoselective acetylation of meso-3-( tert-butyldimethylsiloxy)-2,4-dimethyl-1,5-pentanediol by vinyl acetate in the presence of Candida rugosa lipase in organic medium gave the corresponding (2R, 3R, 4S) mono ester in high enantiomeric purity (ee = 97%). Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/0957-4166(95)00272-Q