Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2–C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminat...

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Published inBioorganic & medicinal chemistry letters Vol. 6; no. 8; pp. 995 - 998
Main Authors Ares, Jeffrey J., Outt, Pamela E., Randall, Jared L., Johnston, Jeffrey N., Murray, Peter D., O'Brien, Linda M., Weisshaar, Pamela S., Ems, Beth L.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 23.04.1996
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Summary:Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2–C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminated when this ring is moved from the 2- to the 3-position. Several analogs of flavone 1 have been synthesized and evaluated for gastroprotective activity. A C2C3 double bond, an intact C ring, and a substituent at C-2 are critical features of gastroprotective compounds.
ISSN:0960-894X
1464-3405
DOI:10.1016/0960-894X(96)00134-5