Chronic HCV infection: An internist's opinion (Part 2)

• Published in: Terapevtic̆eskii arhiv Vol. 88; no. 11; pp. 138 - 148
• Main Authors: Zubkin, M L, Chervinko, V I, Ovchinnikov, Yu V, Kryukov, E V, Kotenko, O N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) "Consilium Medicum" Publishing house 01.01.2016
• Subjects: Antiviral Agents; Attitude; Cardiovascular Diseases - complications; chronic hcv infection; direct-acting antiviral agents; Endocrine System Diseases - complications; extrahepatic manifestations; Hepacivirus; Hepatitis C; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - drug therapy; Humans; Liver Neoplasms - virology; extrahepatic manifestations; direct-acting antiviral agents; chronic HCV infection
• ISSN: 0040-3660; 2309-5342
• DOI: 10.17116/terarkh20168811138-148

Hepatitis C virus (HCV) infection results in not only chronic hepatitis and subsequent complications as liver cirrhosis and hepatocellular carcinoma, but also in a significant number of other diseases, the so-called extrahepatic manifestations of chronic HCV infection. In addition to lymphoproliferative and autoimmune disorders discussed in Part 1 of this review, many other diseases turned to be associated with chronic HCV infection. Part 2 of this review is dedicated to the analysis of the relationship of chronic HCV-infection to the development of some endocrine diseases, such as thyroiditis and diabetes mellitus, and cardiovascular disorders. It also provides the characteristics of the currently available antiviral agents and considers whether they may be used in patents with extrahepatic manifestations of chronic HCV infection.