Herbicide perfluidone (1,1,1-trifluoro- N-[2-methyl-4-(phenylsulfonyl)phenyl]methanesulfonamide): Its metabolism in rats and chickens
Rats and chickens were each given a single oral dose (10 or 100 mg/kg body wt) of 1,1,1-trifluoro- N-[2-methyl-4-(phenylsulfonyl)phenyl- 14C(U)]methanesulfonamide ([ 14C]perfluidone). Depending on the size of the dose, from 8.4 to 36.2% of the [ 14C] was eliminated in the urine and from 36.4 to 85.4...
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Published in | Pesticide biochemistry and physiology Vol. 7; no. 1; pp. 62 - 72 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Inc
01.01.1977
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Online Access | Get full text |
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Summary: | Rats and chickens were each given a single oral dose (10 or 100 mg/kg body wt) of 1,1,1-trifluoro-
N-[2-methyl-4-(phenylsulfonyl)phenyl-
14C(U)]methanesulfonamide ([
14C]perfluidone). Depending on the size of the dose, from 8.4 to 36.2% of the [
14C] was eliminated in the urine and from 36.4 to 85.4% was eliminated in the feces within 48 hr after dosing. Less than 1% of the [
14C] given to laying hens as [
14C]perfluidone was present in the eggs produced during the first 96 hr after dosing. The percentage of the administered [
14C] that remained in these animals (body with G.I. tract and contents removed) varied from 0.34 (96 hr after dosing) to 1.68% (48 hr after dosing).
14C-labeled compunds in the urine and feces from the rats and chickens were purified by solvent extraction, column chromatography, and gas-liquid chromatography, and then identified by infrared and mass spectrometry. The parent compound was the major
14C-labeled component in the urine and feces of both animals. 1,1,1-Trifluoro-
N-[2-methyl-4-(3-hydroxyphenylsulfonyl)phenyl]methanesulfonamide was present in the feces of both animals. The proposed structures of other metabolites were 1,1,1-trifluoro-
N-hydroxy-
N-[2-methyl-4-(phenylsulfonyl)phenyl]methanesulfonamide (rat urine) and 1,1,1-trifluoro-
N-{2-methyl-4-[(methylsulfonyl)-phenylsulfonyl]phenyl}methanesulfonamide (chicken urine). |
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ISSN: | 0048-3575 1095-9939 |
DOI: | 10.1016/0048-3575(77)90067-0 |