A clinico-pathological study of canine Cushing's disease caused by a pituitary carcinoma

• Published in: Journal of comparative pathology Vol. 105; no. 3; pp. 353 - 365
• Main Authors: Boujon, C.E., Ritz, U., Rossi, G.L., Bestetti, G.E.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.10.1991; Elsevier
• Subjects: Adenocarcinoma - complications; Adenocarcinoma - pathology; Adenocarcinoma - secondary; Adenocarcinoma - veterinary; Adrenocorticotropic Hormone - analysis; Animals; Biological and medical sciences; Biomarkers, Tumor - analysis; Brain Neoplasms - pathology; Brain Neoplasms - secondary; Brain Neoplasms - veterinary; Calcinosis - etiology; Calcinosis - pathology; Calcinosis - veterinary; Cushing Syndrome - etiology; Cushing Syndrome - pathology; Cushing Syndrome - veterinary; Dexamethasone; Dog Diseases - pathology; Dogs; Female; Hydrocortisone - blood; Medical sciences; Melanocyte-Stimulating Hormones - analysis; Nervous system involvement in other diseases. Miscellaneous; Neurology; Parathyroid Hormone - blood; Pituitary Neoplasms - complications; Pituitary Neoplasms - pathology; Pituitary Neoplasms - veterinary; Thyrotropin; Thyroxine - blood; Clinic; Fissipedia; Carnivora; Vertebrata; Correlation; Nervous system diseases; Mammalia; Histopathology; Animal; Cushing syndrome; Tumor; Dog
• ISSN: 0021-9975; 1532-3129
• DOI: 10.1016/S0021-9975(08)80203-4

Knowledge of clinico-pathological correlations in canine Cushing's disease is rather poor. Therefore we describe, clinically and pathologically, a case of pituitary tumour-dependent Cushing's disease in an 8-year old female cocker spaniel. Based on our results, the tumour was defined as a non-dexamethasone-suppressive, corticotrophic adenocarcinoma characterized by some new findings such as intracerebral metastases of anti-ACTH-labelled tumour cells and combined α-, β- and γ 3-MSH immunoreactivity in the tumour.