Synthesis of potential bisubstrate inhibitors of Leishmania elongating α- d-mannosyl phosphate transferase

Graphic Synthesis of a potential mechanism-based bisubstrate inhibitor 1 of the elongating α- d-mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues 2 and 3 has been...

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Bibliographic Details
Published inTetrahedron letters Vol. 45; no. 4; pp. 857 - 862
Main Authors Borodkin, Vladimir S., Ferguson, Michael A.J., Nikolaev, Andrei V.
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 19.01.2004
Elsevier
Subjects
Carbohydrates
Chemistry
Chemistry, Organic
Phosphonic acids and derivatives
Physical Sciences
Science & Technology
Transition states
Transition states
Carbohydrates
Phosphonic acids and derivatives
ALCOHOLS
LIPOPHOSPHOGLYCAN
ANALOG
DONOVANI
BIOSYNTHESIS
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Summary:Graphic Synthesis of a potential mechanism-based bisubstrate inhibitor 1 of the elongating α- d-mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues 2 and 3 has been successfully accomplished.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2003.11.022